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Currently Active Research Studies

Novel extracorporeal treatment to modulate hyperinflammation in COVID-19 patients

Principal Investigator: Dr. Christopher McIntyre

We are facing a global COVID-19 outbreak that has forced the majority of the population to stay home. Unfortunately, in severe cases, COVID-19 causes a potentially fatal condition known as acute respiratory distress syndrome (difficulty to breathe). Patients who suffer from severe respiratory illness are admitted to the ICU due to worsening health because of the virus. It is thought that worsening health is caused by a “cytokine storm”. Cytokines are small proteins secreted by cells of the immune system that control inflammation. A cytokine storm refers to an overproduction of these small proteins, which occurs when too many white blood cells (help the body fight infection and other diseases) are activated. In turn, these small proteins activate more white blood cells leading to a vicious cycle. This huge stimulation of inflammation can become damaging to a patient’s organs, leading to multi-organ injury (i.e. lung, heart etc…).


We configured a dialysis machine to hopefully decrease this cytokine storm by inactivating white blood cells through a dialysis circuit. Seven patients have been enrolled in the study in the intensive care unit. When the team started treatment on the first positive COVID-19 patient, they had around a 98% chance of dying and when the team recalculated the score after treatment was complete the patient had about a 30% of dying. We would like to study approximately 40 patients total (20 controls and 20 in the intervention group). If proven successful, the therapy would allow for a reduced intubation time, length of hospital admission, and a decrease in mortality rates.

Check out the latest story here or below 'Canadian research team becomes first in the world to treat COVID-19 patients with dialysis'

Evaluation of Sodium Deposition in Soft Tissues of Patients with Kidney Disease and its Association

Principal Investigator: Dr. Christopher McIntyre

Our body maintains sodium (salt) balance by getting rid of excess sodium through urine. When the kidneys stop working, sodium accumulates in the skin and muscles. We already know that sodium accumulation is higher in men, older patients, and patients with high blood pressure, and that sodium accumulation may have a number of other side effects such as inflammation. We are measuring sodium content in the tissues with magnetic resonance imaging (MRI) in patients at various stages of chronic kidney disease (CKD), on various dialysis therapies, and in patients with heart failure. Based on earlier findings, we know that high sodium concentration is linked to age, high blood pressure, diabetes, and CKD. The threshold of sodium accumulation in peadiatric patients is likely lower, but it has never been explored. Therefore, we began to scan healthy children and those with CKD to determine tissue sodium level. More recently, we have observed more salt in the skin in patients on dialysis and more salt in the skin and muscle in CKD patients stage 1-4. We also observed that skin sodium is higher in patients who have a higher sodium dialysate concentration. Our next question will be, “Is salt in the skin higher in patients who have heart failure with renal dysfunction compared to patients with only heart failure.”

Evaluation of Kidney Medullary Sodium Content using Sodium-23 Magnetic Resonance Imaging to understand and predict diuretic resistance

Principal Investigator: Dr. Christopher McIntyre

Heart failure leads to fluid retention, breathlessness and fatigue and is often associated with kidney failure; this is important because the interaction with kidney failure makes heart failure worse. When the kidneys fail, patients eliminate less water and salt that end up accumulating in the body, increasing the risk of fluid retention and its side effects (i.e. swelling). Diuretics such as Furosemide, also called Lasix work on your kidneys by increasing the amount of water and salt elimination through your urine. Diuretic resistance is when you don’t get enough diuresis (production of urine) thereby failing to achieve a decrease in swelling caused by fluid retention despite being given the maximal dose of diuretic. When there is no or minimal response to diuretics, higher doses of diuretics are often necessary. Diuretic resistance makes it much more difficult for patients to manage water and salt well. At the moment, we have no way of predicting how heart and kidney failure patients will respond to diuretics, and how high a dose they will need. We plan to measure salt content in the kidneys with MRI in order to study the difference in salt content between heart failure patients who respond to diuretics and those who do not respond to diuretics. This study will tell us whether kidney salt content can predict diuretic response in heart failure, and whether sodium MRI can be routinely employed to improve management of diuretic therapy in the future. Seven participants have been scanned to determine the feasibility of the hardware being used. We are now ready to validate that what we have seen in our preliminary work is visualized in patients.

Interventional Study to Assess the Effect of Extended Dialysis using the Theranova Dialyzer on Patient Reported Symptoms using the London Evaluation of Illness (LEVIL)

Principal Investigator: Dr. Christopher McIntyre

We know that many patients who are on dialysis suffer from the burden of unwanted symptoms, which can affect quality of life. In this study, we look at symptom burden using the London Evaluation of illness “LEVIL,” an application based platform where patients can self-report their symptoms with each hemodialysis treatment using an iPad or mobile phone. We look at 9 different symptom domains including general well-being, pain, energy, sleep quality, shortness of breath, appetite, bodily itch, restless legs, and time to recovery.


The Theranova dialyzer is capable of removing large middle molecules (15,000 - 60,000 Da) because of its highly permeable membrane that have been linked to the development of complications such as cardiovascular disease. At this time, enrolment, treatment, and data collection are ongoing and 29 hemodialysis patients have completed the study. We are excited to see if symptoms are related to an increased amount of these uremic toxins in the blood.

Investigation of Electrophysiological Substrate of Arrhythmia in Hemodialysis patients

Principal Investigator: Dr. Christopher McIntyre

Computed tomography (CT) imaging is a useful tool in studying blood flow defects in organs such as the lungs and heart during dialysis treatment. In this study, our aim is to observe the changes in blood flow in the heart muscle during hemodialysis and determine whether or not this response is related to irregular heart rhythms in patients on hemodialysis treatment.

To detect irregular heart rhythms, patients enrolled in this study have a small implantable loop recorder (heart monitoring device) placed directly under the skin near the heart. By doing this, we are able to study a patient’s heart rhythm continuously for up to one year.

Currently, 7 patients have completed the imaging sessions and 3 of these patients have had the loop recorder implanted. Based on the results thus far, there is a general decrease in blood flow in the heart muscle that is strongly evident at 3 hours into dialysis treatment. To relate these blood flow defects to heart rhythm, we will continue to remotely monitor the data obtained from those with the implanted loop recorder.

Preclinical investigation of the effects of hemodialysis on microvascular perfusion.

Principal Investigator: Dr. Christopher McIntyre
Co-Investigator: Dr. Barry Janssen

Patients suffering from kidney disease rely on hemodialysis (HD) for renal replacement therapy. It provides life-saving treatment for kidney failure for around three million people globally and typically consuming 5-10% of total healthcare budget. Unfortunately the quality of life in patients is poor and mortality is high, with cardiovascular disease (CVD) being the leading cause of death. Although this high CVD mortality in renal patients usually directly results from a higher prevalence of an underlying cardiovascular pathology, research has shown that this is further compounded by the additional physiological stress from the HD procedure itself. Research shows that HD induces a maldistribution of blood flow in the microcirculation of tissues,  leaving significant areas in the tissues devoid of blood flow. As such HD can induce recurrent and cumulative ischemic injury to vital organs like the heart, brain, liver and kidney, resulting in cardiac failure and arrhythmia, cognitive impairment, reduced toxin clearance and a reduction of residual renal function, respectively.
 
Investigation of the microcirculation requires the use of intravital microscopy to observe the flow of blood in the small capillaries in the tissue. We developed a small animal model that allows to investigate blood flow during a HD procedure using customized mini-dialyzers.

The versatility of the preclinical small animal model allows for a detailed preclinical investigation of how HD affect microvascular blood flow in tissue. With this model we will investigate how different treatment procedures, new dialyzer designs, membrane materials, or new pharmacological treatment strategies can affect the efficiency of HD. Moreover, in light of the recent COVID19 pandemic, we are currently investigating if a modification of the HD procedure can be used to mitigate the hyperinflammatory response.

Initial feasibility pilot study of interdialytic peritoneal ultrafiltration to manage volume status in hemodialysis patients

Principal Investigator: Dr. Christopher McIntyre

Tissue sodium deposition is harmful to patients on chronic hemodialysis. A sample of 10 chronic hemodialysis patients will undergo a 5-week, pilot, interventional study to test the efficacy of tissue sodium removal in-between hemodialysis sessions, twice per week, for three weeks. Tissue sodium removal will be achieved with a 10% dextrose solution by peritoneal dialysis - all patients will undergo the surgical insertion of a peritoneal dialysis catheter. Patients will undergo symptomatic and hemodynamic monitoring throughout the study for safety assessment. Total tissue sodium removal will be assessed at the beginning and at the end of the study with sodium magnetic resonance imaging.

Fluid Intake After Hemodialysis: Investigating the Relationship between Time and Weight Gain during the Interdialytic Interval

Principal Investigator: Dr. Christopher McIntyre

Interdialytic weight gain determines how much fluid (ultrafiltration) has to be removed during each hemodialysis session. High ultrafiltration volumes stress the organism and lead to a higher risk of death. Thirst is the main driving factor of interdialytic weight gain, and thirst is mainly driven by salt intake, molecules that increase blood tonicity (such as sugar in diabetics) and fluid loss (such as in dehydration and blood loss). It has been speculated that fluid loss during hemodialysis could increase the sense of thirst immediately following dialysis, but this statement requires further evidence. 

We hypothesize that a significant portion of interdialytic weight gain occurs in the first hours following dialysis to compensate for the fluid loss. Therefore, in this observational study, we will have a sample of approximately 20 non-diabetic patients on standard hemodialysis self-monitor their weight gain and blood pressure during the intervals between hemodialysis sessions for a week. Demographics, anthropometrics, questionnaires, hemodialysis prescription and treatment information will also be recorded. Study participants will be provided a digital scale and a blood pressure monitor, and will be asked to prospectively record weight changes and blood pressure four times a day for a week.

Renal Community Photo Initiative

Principal Investigator: Dr. Christopher McIntyre

This collaborative research effort between the Kidney Clinical Research Unit and the Visual Arts Department at Western University is underway to understand how persons with chronic kidney disease, persons receiving chronic dialysis treatments or those who have received a kidney transplant respond to treatment through imagery. Participants are invited to photograph, share and discuss their photos, and experience the images of other participants.

The goals of this project are:
i) to explore how photographic image-making and the use of different camera types can influence the patient photographer, the types of photographs that are produced and those with whom the photos are shared, and
ii) to share these photographs and artistic representations in order to educate, inform and raise awareness among caregivers, healthcare providers, those overseeing policy and funding and key stakeholders.

39 subjects selected one of 4 different cameras or cyanotype paper and participated in the main study with 12 of these participants also in the sub-study. The sub-study was designed to obtain participant feedback regarding use of these images to obtain the study objective. Such visuals include large banners, a “post-card” display, “Bringing Healing into Focus” - a site created by Schulich School of Medicine and Dentistry for their website, media attention from CTV London and a blog written for Home Dialysis Central. Recruitment continues while the study group also explores options to potentially “archive” the images and further share them with a number of communities.

  

Reducing dialysis-associated cardiac injury in acute kidney injury patients undergoing continuous renal replacement therapy by delivering cool blood: a pilot randomized controlled trial.

Principal Investigator: Dr. Marat Slessarev
Co-Investigator: Dr. Christopher McIntyre

Acute kidney injury (AKI) is common in intensive care unit (ICU) patients and is associated with longer hospital stays and worse survival. The mortality rate of critically ill patients in the ICU who receive renal replacement therapy for AKI ranges between 50-80%, cardiovascular disease being the second largest cause of death. A previous pilot study from our group showed that cardiac damage occurs in AKI patients during continuous renal replacement therapy (CRRT) and could contribute to explain the high cardiovascular mortality in this population. In the chronic intermittent dialysis setting, mild dialysate cooling was shown to improve intradialytic hemodynamic stability and prevent cardiac injury. The aim of this study is to find out whether delivering cool blood with CRRT is an effective intervention in preventing cardiac injury in AKI patients.

Reducing hemodialysis induced recurrent brain injury to improve patients' lives

Principal Investigator: Dr. Christopher McIntyre

Chronic kidney disease patients undergoing hemodialysis often begin to experience difficulties with executive function, and the ability to plan and make decisions. These cognitive changes are associated with abnormalities in their brain scans. We believe this arises from issues with blood flow to the brain during and following hemodialysis sessions.

Our group is testing a new therapy which may protect the brain by priming the body with restrictions in blood flow in the lower leg for a few minutes, administered monthly before dialysis treatment. This is safe and it has been shown to prevent injury in other organs, including the liver, kidneys, and heart. The study involves cognitive tests and brain scans before and during dialysis, twice over the course of one year. Follow up scans will help us determine if the new therapy helps to maintain brain health. As well, hemodialysis treatment is often associated with negative complications related to microcirculatory stress (blood vessel injury). It is already shown that cells within the blood vessels respond to injury by releasing biological factors. Of these biological factors in the blood are microparticles, which are fragments of injured cells.

We are currently conducting a research project that focuses on measuring microparticles within the blood of patients who are undergoing hemodialysis. Our research aims to understand if microparticles can be used as an indicator of microcirculatory stress brought upon by dialysis, and to determine whether they can be used to identify if patients are responding to different dialysis modalities.

Does peritoneal dialysis preserve blood brain flow, maintain structure and prevent injury? A neuroimaging study.

Principal Investigator: Dr. Arsh Jain

Abnormalities of cognitive impairment (predominately in decision making) are almost universal in dialysis patients and appear early after starting dialysis. Around 75% of hemodialysis patients’ exhibit mild cognitive impairment (MCI) and a high proportion (~ 15%) have dementia. The injury is multifactorial, and amendable to HD-based intervention. Although the effects of hemodialysis on cerebral blood flow have been well studied, the effects of peritoneal dialysis on cerebral blood flow remain unclear. There is evidence that hemodialysis and peritoneal dialysis may affect the brain differently. In observational studies, peritoneal dialysis compared to hemodialysis is associated with a 16% lower risk of hemorrhagic stroke and a 25% lower risk of a new diagnosis of dementia. It may be that peritoneal dialysis offers a gentler alternative for cerebral blood flow with less acute hemodynamic changes. The purpose of this study is to measure how peritoneal dialysis affects the brain using Magnetic Resonance Imaging (MRI). We plan on recruiting 25 patients from London, Ontario to undergo two study visits, one year apart. There will be two MRI scans at each visit – the first will occur before PD treatment, and the second will occur during PD treatment. Scans will capture images of brain structure, blood flow, and injury. These results will be compared to HD patients. To date, we have recruited 3 patients.

Assessment of Telehome Monitoring in Patients on Peritoneal Dialysis (CONNECT Trial): A Multicentre Randomized Controlled Trial

Principal Investigator: Dr. Arsh Jain

One in 10 Canadians has kidney disease and 39,000 are being treated for complete kidney failure, requiring renal replacement therapy through dialysis or kidney transplantation. The most common forms of dialysis are in-centre hemodialysis and home-based peritoneal dialysis. Peritoneal dialysis (PD) has been shown to have early survival advantage compared to hemodialysis (HD), along with improved quality of life. It has also been found to be the least costly of form of dialysis (suggested savings of about $50,000 per patient per year). However, only 18% of dialysis patients in Canada currently use PD and approximately 10-30% of these patients switch from PD to HD each year. Patients primarily leave PD due to issues with infections and lack of home support. Telehome monitoring, which involves the sharing of digital patient health information between the patient and care provider, is a solution which addresses these two issues. We have implemented a telehome monitoring solution, eQ Connect™, which provides a platform for instructional media and training content, clinical data entry, and video communication, ultimately eliminating barriers for PD retention. This program is delivered on an iPad which replaces the traditional paper and pen PD record. This randomized control trial is taking place at 11 sites across Canada, and began in June 2016 at Victoria Hospital in London. To date, we have recruited 467 participants.

Improving the Outcomes of Peritoneal Dialysis (PD) Catheter Insertion

Principal Investigator: Dr. Arsh Jain

One in five patients on peritoneal dialysis (PD) will experience a PD catheter complication in the first 6 months following insertion. The goal of this research study is to improve the outcomes of PD catheter insertion and to maximize the safe and effective use of PD therapy. Specific aims are: 1) To determine if method of insertion is associated with PD catheter complications. 2) To determine what operator and center characteristics and practices are associated with insertion related complications, with a focus on operator volume. 3) To achieve expert consensus on optimal practices for PD catheter insertion and care using a data driven approach to achieve expert consensus on optimal practices for PD catheter insertion and care.

The Peritoneal Dialysis Outcomes and Practice Patterns Study Phase 2 (PDOPPS2)

Principal Investigator: Dr. Arsh Jain

PDOPPS 2 is a prospective, observational cohort study of PD subjects and facilities in participating countries. It is designed to advance the understanding of optimal practices for peritoneal dialysis (PD) patients worldwide. The study is designed to increase the appropriate use of PD, extend technique survival, reduce mortality, and improve quality of life for PD patients.

 

Up and Coming

Sodium Assessment of the Cardiac Tissue Using Sodium Magnetic Resonance Imaging

Principal Investigator: Dr. Christopher McIntyre

Chronic kidney disease (CKD) is extremely prevalent worldwide and affects around 10% of people living in developed health economies. Patients with CKD have damaged kidneys that are not able to filter their blood as well as healthy individuals. The most critical ion that is excreted and regulated by the kidneys is sodium. In patients with CKD, their damaged kidneys can cause inadequate removal and accumulation of sodium. This has been found to occur in the heart muscle and could drive the development of fibrosis which contributes to heart failure.

Using sodium magnetic resonance imaging (MRI), it is possible to measure the sodium content in the cardiac tissue of patients with kidney disease.


Study Objective: We will investigate whether the elevated levels of sodium in patients with kidney disease is also present in their hearts, and if so, whether this relates to cardiac abnormalities. Cardiac sodium MRI images of healthy volunteers, hemodialysis patients, and CKD patients stage 1-5 will be analyzed for sodium content. This sodium information will then be compared to the biomarkers of fibrosis measured from each patient’s proton MRI images in order to establish a possible correlation. This research has the potential to precede additional studies that may investigate the effect of diuretics on the cardiac tissue of kidney disease patients.


Hypotheses: 

  1. CKD and HD patients have larger cardiac sodium deposits compared with healthy individuals.

  2. Cardiac sodium deposits are correlated with left ventricular mass and cardiac T1 and T2 times.

  3. Cardiac sodium deposits are correlated with male sex, older age, dialysate composition, serum biomarkers of kidney function, inflammation, microvascular and cardiac function.


Study Design: This is a single center observational pilot


Once recruited, participants will undergo one study visit (on a non-dialysis day for hemodialysis patients). Each study visit will include, blood pressure and heart rate measurements, measurement of advanced glycation end products (AGEs) using the AGE Reader, blood work, a spot urine test, a sodium intake questionnaire, a single time to recovery question, a proton MRI scan, and an MRI scan of the cardiac tissue detecting sodium content.


Study Population: We will recruit up to 150 participants: approximately 50 hemodialysis patients, 50 patients with various stages of chronic kidney disease

Control: 50 healthy controls

Intervention: MRI scan (1H & 23Na) of the kidneys

Primary Outcome: Difference in Cardiac Sodium Signal between 1) chronic in-center hemodialysis patients, 2) CKD stage 3-5 patients and 3) sex and age-matched healthy adult controls

Secondary Outcomes: 

  • Correlation between Cardiac Sodium Signal and:

    • Demographics (i.e. Age, Sex)

    • Dialysate composition (in HD patients)

    • Left Ventricular Mass

    • Left Ventricular Volume

    • Left Atrial Volume

    • Septal T1 and T2 times

    • Total Body Water and Extracellular Volume (Bioimpedance Spectroscopy)

    • Biochemistry biomarkers: uremic toxins, inflammatory, cardiac and microvascular biomarkers, serum albumin, estimated glomerular filtration rate (cystatin C) and high-sensitivity troponin T

Kidney sodium functional imaging: evaluation of kidney medullary sodium content using 23Na MRI in kidney disease

Principal Investigator: Dr. Christopher McIntyre

Maintenance of the corticomedullary gradient (CMG) is required for urine concentration and is one of the most important tubular functions allowing humans to live in a warm environment. However, functional tubular parameters to assess directly CMG are lacking. Sodium magnetic resonance imaging (23Na MRI) is a noninvasive tool that has successfully measured directly CMG dynamic changes in healthy volunteers. Because CMG measurement may provide a relevant assessment of tubular dysfunction independently of glomerular alteration, we propose to explore CMG in patients with a large range of kidney disease, from chronic kidney disease to dialysis or transplanted patients.

Study Objective: To determine the corticomedullary gradient in patients with different types and levels of kidney disease and provide the first application of renal tubular functional MRI

Hypothesis: 23Na kidney MRI, will provide functional MR of the kidney as a non-invasive tool to describe medullary function in order to improve management of chronic and acute kidney disease

Study Design: Pilot, cross-sectional, observational study

Once enrolled, participants will undergo one study visit (on a non-dialysis day for hemodialysis patients). The study visit will include, blood pressure and heart rate measurements, measurement of advanced glycation end products (AGEs) using the AGE Reader, blood work, urine collection (excluding those on dialysis), 24 hr urine volume test for patients who have had kidney stones, and an MRI scan of the kidneys detecting sodium content

Study Population: 60 patients with various stages of chronic kidney disease, 40 transplanted patients, 40 dialysis patients, 40 patients with autosomic dominant polycystic kidney disease (ADPKD), and 40 patients with nephrolithiasis

Control: 40 healthy controls including kidney donors

Intervention: Sodium content measurement in cortex and medulla with 23Na MRI

Primary Outcome: Exploratory cortico-medullary gradient measurement in a large range of kidney disease by measuring sodium medullary to cortex ratio with23Na kidney MRI in: 1) stage 1-5 CKD patients 2) transplanted patients 3) dialysis patients 4) patients with acute kidney injury 5) ADPKD patients 6) nephrolithiasis patients (characteristically associated with salt loading) 7) healthy controls


Secondary Outcomes:

1. To evaluate the relationship between sodium medullary to cortex ratio and urinary osmolarity;

2. To evaluate the relationship between sodium medullary to cortex ratio and renal function;

3. To compare sodium medullary to cortex ratio t between native kidney and transplanted kidney;

4. To compare sodium medullary to cortex ratio between transplanted kidney and kidney biopsy;

5. To evaluate accuracy to detect acute kidney injury with 23NaMRI;

6. To evaluate sodium medullary to cortex ratio in dialysis patients and renal residual function; 

7. To compare sodium medullary to cortex ratio between healthy control and patients who have nephrolithiasis;

8. To evaluate the ability to measure sodium medullary to cortex ratio in autosomal dominant polycystic kidney disease;

9. To determinate if measurement of sodium medullary to cortex ratio measurement is meaningful in clinical practice.

Trial of Intradialytic Cycling as Kidney Exercise Rehabilitation for cardiac Stunning in Hemodialysis (TICKERS_HD)

Principal Investigator: Dr. Christopher McIntyre

People with kidney failure receiving chronic hemodialysis (HD) suffer from fatigue post treatment, poor functional status and high rates of cardiac failure and death. Previous work has shown that these outcomes are correlated with recurrent ischemic cardiac injury (myocardial stunning) that occurs during HD treatments. Myocardial stunning, identified by regional cardiac wall motion abnormalities (RWMAs), is common during HD. Intradialytic cycling (during HD) decreases HD-induced stunning, and may improve adverse outcomes associated with stunning. We will use echocardiography (echo) and a validated cardiac biomarker to understand the effects of intradialytic aerobic exercise on myocardial stunning and HD-related symptoms.

Research Question: Compared to current standard of care, does participation in a 12-week aerobic exercise program during HD decrease HD-induced myocardial stunning as measured by the change in number of cardiac RWMAs from baseline to peak HD stress (last 30 minutes of HD)?

Hypothesis: Intradialytic aerobic exercise will provide protection against HD-induced myocardial stunning immediately after starting the exercise program. Furthermore, exercise training for 12 weeks will lead to progressive decline in HD-induced myocardial injury, HD-related fatigue, and symptom burden, and will result in improved cardiac function over time.

Primary Aim: To determine the effect of 12-weeks of intradialytic cycling on HD-induced myocardial stunning in adults on chronic HD;

Secondary Aims: 

1. To correlate HD-induced myocardial stunning with high sensitivity troponin T (hsTnT), a validated biomarker for cardiac injury;

2. To characterize the effect of 12 weeks of intradialytic cycling on post-HD fatigue and symptom burden;

3. To explore the “off treatment effect” of intradialytic cycling on HD-induced myocardial stunning;

4. To gather feasibility data to inform the design of an innovative multicentre clinical trial investigating the effect of exercise during HD on long term cardiac outcomes.


Study Design: Multicentre, assessor blinded RCT with 1:1 parallel group design, and allocation concealment comparing change in HD-induced myocardial stunning in 80 HD patients participating in 12 weeks of cycling during HD compared to 80 HD patients receiving standard HD care.

Study Population: All adults receiving chronic HD (3 times/week) at in-centre HD units in the 7 participating sites will be eligible.

Intervention: Participants will receive baseline exercise counselling as per controls and then participate in a supervised 12-week intradialytic cycling program.


Primary Outcome: Change in HD-induced myocardial stunning measured by change in number of RWMAs at peak HD stress (~30 minutes before the end of HD) from baseline to 12 weeks as measured by intradialytic echo.

Secondary Outcomes:

1. Change in pre-HD hsTnT level from baseline 12 weeks as measured by Roche High-Sensitivity Troponin TTM assay at each site;

2. Change in severity of post-hemodialysis fatigue will be assessed by the self-reported answer to the question: “How long does it take you to recover from a dialysis session and resume your normal, usual activities?”;

3. Symptom burden measured using the Dialysis Symptom Index Severity Score;

4. Exercise capacity measured by Incremental Shuttle Walk Test;

5. Change in physical activity behaviour patterns assessed using total active minutes per day as measured by multi-directional accelerometry;

6. Change in number of RWMAs at peak HD stress at each study time point will be measured to further

assess how exercise training affects HD-related myocardial stunning over time;

7. Feasibility data collected will include eligibility, recruitment, adherence to exercise, retention rates and site-specific barriers.

 

Canadian team first in world to treat COVID-19 with specialized dialysis